Evidence for the digital programming of cellular differentiation: characterization of binary switches in lineage-determining transcription factors
Hongchuan Li, Md Ahasanur Rahman, Michael Ruesch, Caprice D. Eisele, Erik M. Anderson, Paul W. Wright, Jennie Cao, Shashikala Ratnayake, Qingrong Chen, Chunhua Yan, Daoud M. Meerzaman, Roshini Sarah Abraham, Aharon G. Freud, Stephen K. Anderson
The paper identifies binary promoter switches in lineage-determining transcription factors, showing mutually exclusive sense/antisense transcription and distinct gene expression patterns in different cell states.
Cell Reports · Nov 1, 2023Peer-reviewedDevelopmental Biology