Chunhua Yan

The paper develops a hybrid retrieval system for mapping source data elements to CDEs, achieving high recall across multiple datasets.

The paper identifies binary promoter switches in lineage-determining transcription factors, showing mutually exclusive sense/antisense transcription and distinct gene expression patterns in different cell states.

This study evaluates reproducibility and accuracy of cancer mutation detection using whole-genome and whole-exome sequencing across multiple sequencing centers and bioinformatics pipelines.

scCorr reduces zero values in single-cell RNA-seq by merging homology cells, improving gene-gene correlation detection for network analysis.

This study evaluates somatic CNV callers using NGS data from 91 samples with varying factors, finding that caller choice and tumor purity significantly impact call quality.

This study identifies 294 genes affected by acute THC administration in human immune cells, including 69 common and 225 cell-type specific genes.