Qingrong Chen

The paper develops a hybrid retrieval system for mapping source data elements to CDEs, achieving high recall across multiple datasets.

This study shows that distributed clonal deletion checkpoints prevent autoimmune disease by restricting autoreactive B cell diversification and persistence.

This paper compares two 3D culture models for breast cancer cells, finding that the EmC model better mimics lung metastasis by altering metabolism and gene expression.

This paper develops a scalable method to generate pure CD103+ cDC1 from mouse bone marrow cultures, achieving high purity and yield for immunological studies.

This paper identifies CHMP5 as a nuclear factor that promotes T cell leukemia by enhancing BRD4-p300-dependent transcription at enhancers and super-enhancers.

This study shows TRAIL treatment of TNBC cells activates the NFKB2 pathway, leading to cytokine production that enhances neutrophil chemotaxis and immune suppression.

The paper identifies binary promoter switches in lineage-determining transcription factors, showing mutually exclusive sense/antisense transcription and distinct gene expression patterns in different cell states.

The paper establishes reference samples with high-coverage whole-genome sequencing to create truth sets for somatic mutation and germline variant detection using NGS technologies.

This study evaluates reproducibility and accuracy of cancer mutation detection using whole-genome and whole-exome sequencing across multiple sequencing centers and bioinformatics pipelines.

This study evaluates somatic CNV callers using NGS data from 91 samples with varying factors, finding that caller choice and tumor purity significantly impact call quality.

This study shows BRD4 influences alternative splicing by interacting with splicing machinery during transcription elongation in thymocytes and T-ALL cells.