Mechanism of neurodegeneration mediated by clonal inflammatory microglia
Rocío Vicario, Stamatina Fragkogianni, Maria V. Pokrovskii, Carina Meyer, Estibaliz Lopez-Rodrigo, Yang Hu, Masato Ogishi, Araitz Alberdi, Ann Baako, Oyku Ay, Isabelle Plu, Véronique Sazdovitch, Sébastien Héritier, Fleur Cohen Aubart, Natalia Shor, , Frédéric Geissmann
The paper identifies clonal inflammatory microglia as a cause of neurodegeneration in LCH and ECD, showing their association with neuronal loss and suggesting CSF1R inhibitors as a therapeutic option.
Neuron · Mar 12, 2025Peer-reviewedImmunology