Structural Basis of Second-Generation HIV-1 Maturation Inhibitor Activity by Magic Angle Spinning NMR
Kiran Kumar, Roman Zadorozhnyi, Timothy N. Porter, Jayden A. Martinez, Caitlin M. Quinn, Sherimay D. Ablan, Eric O. Freed, Theodore J. Nitz, Carl T. Wild, Barbie K. Ganser-Pornillos, Owen Pornillos, Angela M. Gronenborn, Tatyana Polenova
This study uses MAS NMR to determine the binding mode of HRF-4467, a second-generation HIV-1 maturation inhibitor, in the CA-SP1-NC11 complex with IP6, revealing its mechanism of action and resistance profile.
bioRxiv · Nov 6, 2026 · PreprintBiophysics