A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis
Roxane Darbousset, Gonzalo Villanueva-Martín, Julia Kuehn, Stefano Navarro, Spoorthi Balu, Dhruv Miglani, Eilish Dillon, Caroline Fromson, Leetah Senkpeil, Mehreen Elahee, Pierre‐André Jarrot, Sydney B. Montesi, Deepak A. Rao, Jerry L. Ware, Denisa D. Wagner, , Peter Andrija Nigrovic
This study identifies a GPVI-platelet-neutrophil-NET axis that drives systemic sclerosis fibrosis and presents it as a therapeutic target.
bioRxiv · Jan 21, 2025 · PreprintImmunology