Author

Roxane Darbousset

Boston Children's HospitalORCID 0000-0002-9868-3799Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

Peter Andrija NigroviciD· 4 shared María Gutiérrez‐ArcelusiD· 3 shared Deepak A. RaoiD· 2 shared Dhruv Miglani· 2 shared Jeffrey A. SparksiD· 2 shared Nicolaj S. HackertiD· 2 shared Raquel Laza BriviescaiD· 2 shared Spoorthi Balu· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersImmunology

Peter Andrija NigrovicORCID

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4 papers

Recent·Most cited

A multi-omics resource of B cell activation reveals genetic mechanisms for immune-mediated diseases

Vitor R. C. Aguiar, Marcella E. Franco, Nada Abdel Aziz, Daniela Fernandez‐Salinas, Marcos Chiñas, Mariasilvia Colantuoni, Qian Xiao, Nicolaj S. Hackert, Yifei Liao, Rodrigo Cervantes‐Díaz, Marc Todd, Brian Wauford, Alex Wactor, Vaishali Prahalad, Raquel Laza Briviesca, , María Gutiérrez‐Arcelus

This study profiles B cell activation states using multi-omics data to identify genetic mechanisms underlying immune-mediated diseases.

Nature Communications · Oct 23, 2026Peer-reviewedGenetic & Genomic Medicine

Megakaryocyte emperipolesis arms neutrophils via intracellular provisioning

Julia K. Kuehn, Geon Ho Bae, Roxane Darbousset, Frank Y. Huang, Rebecca M. Hall, Josephin E. Schiffer, Dhruv Miglani, Spoorthi Balu, Alexandra Wactor, Dorsaf Ghalloussi, Olga Barreiro, Li Guo, Andrew S. Weyrich, Simon J. Cleary, Matthias Gunzer, , Peter Andrija Nigrovic

The paper identifies emperipolesis as a process where megakaryocytes transfer proteins to neutrophils, enhancing their immune function and migration.

bioRxiv · Aug 9, 2026 · PreprintImmunology

A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis

Roxane Darbousset, Gonzalo Villanueva-Martín, Julia Kuehn, Stefano Navarro, Spoorthi Balu, Dhruv Miglani, Eilish Dillon, Caroline Fromson, Leetah Senkpeil, Mehreen Elahee, Pierre‐André Jarrot, Sydney B. Montesi, Deepak A. Rao, Jerry L. Ware, Denisa D. Wagner, , Peter Andrija Nigrovic

This study identifies a GPVI-platelet-neutrophil-NET axis that drives systemic sclerosis fibrosis and presents it as a therapeutic target.

bioRxiv · Jan 21, 2025 · PreprintImmunology

Non-coding autoimmune risk variant accelerates T peripheral helper cell development via ICOS

Taehyeung Kim, Marta Martínez‐Bonet, Qiang Wang, Nicolaj S. Hackert, Jeffrey A. Sparks, Yuriy Baglaenko, Byunghee Koh, Roxane Darbousset, Raquel Laza Briviesca, Xiaoting Chen, María Gutiérrez‐Arcelus, Harm-Jan Westra, Matthew T. Weirauch, Soumya Raychaudhuri, Deepak A. Rao, Peter Andrija Nigrovic

The paper identifies a non-coding variant that increases ICOS expression, leading to more T peripheral helper cells and contributing to autoimmune diseases.

bioRxiv · Dec 16, 2022 · PreprintGenetics