Multimodal characterization and optogenetic potential of the bistable Gi/o-coupled vertebrate ancient opsin from the flashlight fish Anomalops katoptron
Lennard Rohr, Daniel Zhornist, Ori Berman, Christiane Ruse, Marius Seidenthal, Genevieve M. Auger, Caroline Naber, Alina Kirchhof, Caroline I. Güers, Melanie D. Mark, Till Rudack, Peter Soba, ALEXANDER R. GOTTSCHALK, Moran Shalev-Benami, Ida Siveke, Stefan Herlitze
This study characterizes AkVAL, a bistable opsin from the flashlight fish, showing its ability to control neuronal activity and body movement in response to light cycles, suggesting its potential as an optogenetic tool.
bioRxiv · Feb 20, 2025 · PreprintNeuroscience