Christiane Ruse

Stabilized ion selectivity corrects activation drift in kalium channelrhodopsins

The paper identifies a KCR1 variant, C29D, that maintains stable potassium selectivity and provides reliable optogenetic inhibition across species and conditions.

Multimodal characterization and optogenetic potential of the bistable Gi/o-coupled vertebrate ancient opsin from the flashlight fish Anomalops katoptron

This study characterizes AkVAL, a bistable opsin from the flashlight fish, showing its ability to control neuronal activity and body movement in response to light cycles, suggesting its potential as an optogenetic tool.

Loss of neuropeptidergic regulation of cholinergic transmission induces CaV1-mediated homeostatic compensation in muscle cells

The paper shows that loss of neuropeptide signaling in C. elegans leads to increased muscle excitability via CaV1 channels to compensate for reduced cholinergic transmission.

Potassium-selective channelrhodopsins can exert hyper- or depolarizing effects in excitable cells of Caenorhabditis elegans, depending on experimental condition

This study evaluates the use of potassium-selective channelrhodopsins (KCRs) for hyperpolarizing C. elegans cells, finding that their effectiveness depends on illumination parameters and can sometimes induce depolarization.