Rebecca L. Melton

The paper constructs a healthy human pancreas reference atlas to contextualize disease states and benchmark models.

This study uses single-cell and spatial profiling to identify cellular and molecular drivers of beta cell dysfunction in the pancreas of cystic fibrosis patients.

This study uses single-cell multiomics and spatial transcriptomics to identify gene regulatory programs in pancreatic cell types that drive type 1 diabetes progression.

This study uses single-cell multi-omics to identify cell type-specific regulatory networks and novel therapeutic targets in MASLD.

The paper integrates single-cell multi-omics and 3D genome data from human hearts to identify gene regulatory changes and causal genetic contributors in heart failure.

The paper identifies causal biomarkers for type 1 diabetes using protein QTLs and GWAS, revealing roles of pancreatic enzymes and immune processes in disease risk.

The paper creates an integrated gene expression map of pancreatic islet cell types from healthy and diabetic donors, identifying marker genes and differential expression patterns.

This study combines large-scale GWAS and single-cell epigenomics to identify cell type-specific mechanisms of type 1 diabetes risk.