Author

Cassandra M. Hartle

Geisinger Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1

Frequent Co-Authors

Tooraj MirshahiiD· 2 shared Brian P. DelisleiD· 1 shared Geraldine San RamoniD· 1 shared John Smith Del RosarioiD· 1 shared Kalyan ImmadisettyiD· 1 shared Peter Michael Kekenes-HuskeyiD· 1 shared Songxue SuiD· 1 shared Thomas P. McCoyiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioinformatics

Tooraj MirshahiORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Prediction of Kv11.1 potassium channel PAS-domain variants trafficking via machine learning

Kalyan Immadisetty, Xuan Fang, Geraldine San Ramon, Cassandra M. Hartle, Thomas P. McCoy, Tooraj Mirshahi, Brian P. Delisle, Peter Michael Kekenes-Huskey

This study uses machine learning and molecular dynamics simulations to predict which KCNH2 variants disrupt Kv11.1 channel trafficking, improving variant classification accuracy by ~10%.

Journal of Molecular and Cellular Cardiology · May 15, 2023Peer-reviewedBioinformatics

Gi-Coupled Receptor Activation Potentiates Piezo2 Currents via Gβγ

John Smith Del Rosario, Yevgen K. Yudin, Songxue Su, Cassandra M. Hartle, Tooraj Mirshahi, Tibor Rohács

This study shows that Gi-coupled receptor activation enhances Piezo2 currents through Gβγ signaling in DRG neurons and heterologous systems.

EMBO Reports · Mar 29, 2020Peer-reviewedNeuroscience