In Silico Transcriptome-based Screens Identify Epidermal Growth Factor Receptor Inhibitors as Therapeutics for Noise-induced Hearing Loss
Sarath Vijayakumar, Joseph DiGuiseppi, Parinaz J. Dabestani, William G. Ryan, René Vielman Quevedo, Yuju Li, Jack Diers, Shu Tu, Jonathan P. Fleegel, Cassidy Nguyen, Lauren M. Rhoda, Ali Sajid Imami, Abdul-Rizaq Ali Hamoud, Sándor Lovas, Robert Erne McCullumsmith, , Jian Zuo
This paper identifies EGFR inhibitors as potential therapeutics for noise-induced hearing loss using in silico transcriptome-based drug screening and experimental validation in zebrafish and mouse models.
Science Advances · Jun 19, 2024Peer-reviewedNeuroscience