Ali Sajid Imami

The paper characterizes kinase signaling pathways in astrocytes and microglia, revealing cell- and sex-specific activity patterns that differ from transcriptional profiles.

This study investigates how central leptin affects energy homeostasis and metabolism in rats exposed to olanzapine, finding that leptin's effects on food intake and fat oxidation are not blocked by olanzapine.

This study shows that low-dose developmental exposure to deltamethrin disrupts molecular pathways related to circadian rhythms and MAP kinase in mouse brains, linking it to ADHD-like behaviors.

This study identifies elevated mRNA expression of AKT isotypes in schizophrenia neurons, suggesting a potential decoupling of transcript and protein levels, with sex-specific differences and involvement of related signaling components.

This paper identifies EGFR inhibitors as potential therapeutics for noise-induced hearing loss using in silico transcriptome-based drug screening and experimental validation in zebrafish and mouse models.

This study shows that developmental exposure to pyrethroid pesticide deltamethrin disrupts brain metabolism in adult male mice, affecting folate, retinol, tryptophan, and dopamine signaling pathways.

The paper identifies five core protein kinases in neurons and astrocytes from familial AD patient iPSCs and examines their enriched pathways using a combination of experimental and in-silico approaches.

This paper reviews signature-based in silico approaches for drug repurposing in CNS disorders, integrating data science platforms to improve clinical relevance and address regulatory and knowledge challenges.