Multiplex-GAM: genome-wide identification of chromatin contacts yields insights not captured by Hi-C
Robert A. Beagrie, Christoph J. Thieme, Carlo Annunziatella, Catherine Baugher, Yingnan Zhang, Markus Schueler, Alexander Kukalev, Rieke Kempfer, Andrea M. Chiariello, Simona Bianco, Yichao Li, Trenton J. Davis, Antonio Scialdone, Lonnie R. Welch, Mario Nicodemi, Ana Pombo
The paper introduces multiplex-GAM, a ligation-free method for genome-wide chromatin contact mapping, showing it detects different strong contacts compared to Hi-C, particularly involving active genomic regions.
Nature Methods · Jun 19, 2023Peer-reviewedMolecular Biology