Targeting the acetyltransferase NAT10 corrects pathologies in human frontotemporal dementia neurons and extends lifespan in an in vivo Drosophila tauopathy model
Francesco Paonessa, Bernardo Delarue Bizzini, Tom Campbell, Ravi Solanki, Richard Butler, James C. Smith, Catherine M. Davidson, Delphine Larrieu, Andrea H. Brand, Frederick J. Livesey
The paper shows that inhibiting NAT10 corrects nuclear defects and extends lifespan in tauopathy models.
bioRxiv · Oct 19, 2024 · PreprintNeuroscience