Author

James C. Smith

University of CambridgeORCID 0000-0001-9131-5849Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Frederick J. LiveseyiD· 3 shared Lewis EvansiD· 2 shared Alastair D. ReithiD· 1 shared Alessio StranoiD· 1 shared Andrea H. BrandiD· 1 shared Andrew Billinton· 1 shared Andrew R. Bassett· 1 shared Ashley Campbell· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Frederick J. LiveseyORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 19, 2024

Targeting the acetyltransferase NAT10 corrects pathologies in human frontotemporal dementia neurons and extends lifespan in an in vivo Drosophila tauopathy model

Francesco Paonessa, Bernardo Delarue Bizzini, Tom Campbell…·Frederick J. Livesey

The paper shows that inhibiting NAT10 corrects nuclear defects and extends lifespan in tauopathy models.

1 citation

humanDrosophila

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NeurosciencebioRxivPreprintAug 11, 2020

Whole genome CRISPR screens identify a LRRK2-regulated pathway for extracellular tau uptake by human neurons

Lewis Evans, Alessio Strano, Eleanor J. Tuck…·Frederick J. Livesey

The paper identifies LRRK2-regulated pathways for extracellular tau uptake in human neurons using CRISPR screens, showing LRRK2's role in monomeric tau endocytosis.

19 citations

humanCRISPR screen

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NeuroscienceCell ReportsPeer-reviewedMar 1, 2018

Extracellular monomeric and aggregated tau efficiently enter human neurons through overlapping but distinct pathways

Lewis Evans, Thomas Wassmer, Graham Mathew Fraser…·Frederick J. Livesey

The paper investigates how monomeric and aggregated tau enter human neurons through distinct pathways, identifying dynamin- and actin-dependent mechanisms for monomeric tau and dynamin-dependent clathrin-mediated endocytosis for aggregated tau.

192 citationstop 1%

humanexperimental assay

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