The architecture of the endoplasmic reticulum is regulated by the reversible lipid modification of the shaping protein CLIMP-63
Patrick A. Sandoz, Robin A. Denhardt-Eriksson, Laurence Abrami, Luciano Abriata, Gard Spreemann, Catherine Maclachlan, Sylvia Ho, Béatrice Kunz, Kathryn Hess, Graham Knott, Vassily Hatzimanikatis, F. Gisou van der Goot
This paper shows that ZDHHC6-mediated S-palmitoylation of CLIMP-63 regulates ER morphology by controlling its localization and abundance in mammalian cells.
bioRxiv · Oct 1, 2018 · PreprintCell Biology