This study shows that CLIMP-63's luminal domain forms flexible trimers and its cytosolic tail mediates clustering, together determining ER sheet width.

bioRxiv · Jul 1, 2026 · PreprintCell Biology

Molecular Regulation and Physiological Role of 1 GOLPH3-mediated Golgi retention

Anastasia Theodoropoulou, Anita Nasrallah, Luciano A. Abriata, Laurence Abrami, Juliane Da Graça, Irmak Kaysudu, Francesco Talotta, María J. Marcaida, Muhammad U. Anwar, Ondrej Kováč, Sergey Y. Vakhrushev, Alejandro Alonso Calleja, Sylvia Ho, Antonino Asaro, Francisco Sarmento Mesquita, , Giovanni D’Angelo

This study investigates the role of GOLPH3 in Golgi retention and trafficking, showing its regulation by S-acylation and its impact on glycosylation and development.

Nature Communications · Jun 11, 2026Peer-reviewedCell Biology

Ether lipid remodeling during neuronal differentiation prevents ferroptosis

Antonino Asaro, Gregor P. Jose, Ilias Gkikas, Sarah Salame, Pauline Perne, Jean Andrea Maillat, Sylvia Ho, Océane Buvry, Lucile Fleuriot, Eva Bastida‐Martínez, Jeremy Vicencio, Julián Cerón, Yuki Matsuzawa, Frédéric Brau, Julie Cazareth, , 武士原山

This study shows that ether lipid remodeling during neuronal differentiation prevents ferroptosis by balancing pro- and anti-ferroptotic effects through vinyl ether bonds.

bioRxiv · May 6, 2026 · PreprintCell Biology

The architecture of the endoplasmic reticulum is regulated by the reversible lipid modification of the shaping protein CLIMP-63

Patrick A. Sandoz, Robin A. Denhardt-Eriksson, Laurence Abrami, Luciano Abriata, Gard Spreemann, Catherine Maclachlan, Sylvia Ho, Béatrice Kunz, Kathryn Hess, Graham Knott, Vassily Hatzimanikatis, F. Gisou van der Goot

This paper shows that ZDHHC6-mediated S-palmitoylation of CLIMP-63 regulates ER morphology by controlling its localization and abundance in mammalian cells.

bioRxiv · Oct 1, 2018 · PreprintCell Biology