Author

Catherine Maclachlan

The Francis Crick InstituteORCID 0000-0002-3606-6672Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Catherine Maclachlan1 paper

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Assay:electronic health records· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

Christopher J. PeddieiD· 2 shared James R. EvansiD· 2 shared Lucy CollinsoniD· 2 shared Mathew H. HorrocksiD· 2 shared Sonia GandhiiD· 2 shared Adam G. McleaniD· 1 shared Alana BurrelliD· 1 shared Alexandre ChappardiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Christopher J. PeddieORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

VP-CLEM-Kit: An accessible pipeline for visual proteomics using super resolution volume correlative light and electron microscopy (SR-vCLEM)

Dumisile Lumkwana, Jonathan Lightley, Arturo G. Vesga, Joost de Folter, Marie‐Charlotte Domart, Catherine Maclachlan, Sunil Kumar, James Evans, Christopher J. Peddie, Alana Burrell, Azumi Yoshimura, Asandile Mangali, Nicola Vahrjmeijer, Meenal Bhaga, Catherine Smit, , Lucy Collinson

The paper introduces VP-CLEM-Kit, a cost-effective SR-vCLEM pipeline for visual proteomics, achieving 5-fold resolution improvement at 7-fold lower cost.

bioRxiv · Apr 8, 2025 · PreprintCell Biology

Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity

Minee L. Choi, Alexandre Chappard, Bhanu Singh, Catherine Maclachlan, Margarida Rodrigues, Evgeniya I. Fedotova, Alexey V. Berezhnov, Suman De, Christopher J. Peddie, Dilan S. Athauda, Gurvir S. Virdi, Weijia Zhang, James R. Evans, Anna I. Wernick, Zeinab Shadman Zanjani, , Sonia Gandhi

The paper tracks α-synuclein conformational changes in neurons and shows mitochondrial involvement in oligomerization and toxicity.

Nature Neuroscience · Aug 30, 2022Peer-reviewedNeuroscience

Maturation of complex synaptic connections of layer 5 cortical axons in the posterior thalamic nucleus requires SNAP25

Shuichi Hayashi, Anna Hoerder‐Suabedissen, Emi Kiyokage, Catherine Maclachlan, Kazunori Toida, Graham William Knott, Zoltán Molnár

This study shows that SNAP25 is required for the maturation of complex synaptic connections in layer 5 cortical axons in the posterior thalamic nucleus, but not for their initial formation.

Cerebral Cortex · Dec 20, 2020Peer-reviewedNeuroscience