LVV SMRTcap reveals extensive proviral variation in lentiviral vector-transduced CAR T cells
Catherine W. Kaiser, Ghazal S. Mehs, Erin M. Elliott, Joanna Jasinska Mroczkowska, Jain Ankita, Michael J. Ferguson, Alfred L. Garfall, Frederic D. Bushman, Joseph A. Fraietta, Eric Christian Rouchka, Melissa L. Smith
The paper uses long-read sequencing to analyze proviral variation in lentiviral vector-transduced CAR T cells, finding deletions and mutations affecting transgene function.
bioRxiv · May 15, 2026 · PreprintCancer Biology