Noemi Linden

Dynamic Antigen Expression and Intrinsic CTL Resistance in HIV Reservoir Clones

This study characterizes HIV reservoir clones and shows they can be culled by sustained CTL pressure, with some displaying intrinsic resistance linked to low oxidative stress.

Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes

The paper introduces HIV SMRTcap, a method for characterizing HIV-1 reservoirs by identifying integration sites and proviral integrity using long-read sequencing, and validates its performance across subtypes and tissue samples.

HIV-1 expression is heterogeneous among clones of CD4+ T cells carrying authentic intact latent proviruses

The paper examines HIV-1 expression in CD4+ T cell clones with latent proviruses, finding heterogeneous expression and limited response to latency reversing agents.

The EZH2 inhibitor tazemetostat mitigates HIV immune evasion, reduces reservoir formation, and promotes durable CD8+ T-cell revitalization

The paper shows that tazemetostat reduces HIV reservoirs and improves CD8+ T-cell function by increasing MHC-I expression and promoting anti-HIV immune responses.

Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4+ T-cells

Transcription of HIV-1 at sites of intact latent provirus integration

This study examines transcription of HIV-1 at sites of intact latent provirus integration in T cells, finding that latent proviral promoters are significantly less active than in productively infected cells and have minimal impact on neighboring gene expression.