Frederic D. Bushman

This paper evaluates virome analysis methods using a synthetic viral community, finding that VLP enrichment improves read yields and longer sequencing cycles enhance genome assembly.

The paper uses long-read sequencing to analyze proviral variation in lentiviral vector-transduced CAR T cells, finding deletions and mutations affecting transgene function.

This study presents the first structures of a Redondovirus Rep protein, revealing conformational changes linked to its helicase and endonuclease functions during viral DNA replication.

The paper shows that suppressing both COX-1 and COX-2 does not cause intestinal injury in mice unless combined with specific NSAIDs, and that gut microbiome changes amplify NSAID-induced enteropathy.

The paper introduces a combined enzymatic and computational pipeline to identify off-target base-editing sites in human cells on a genome-wide scale.

This paper develops a novel lentiviral vector for gene therapy of MLD that achieves high ARSA activity with minimal genomic integrations, improving safety and efficacy in preclinical models.

This study compares the metabolomic effects of naproxen and celecoxib in humans and mice, finding that naproxen reduces tryptophan levels independently of Cox-2 inhibition.

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

The paper reports and compares B.1.1.7+E484K SARS-CoV-2 isolates from Pennsylvania, identifying 7 clonal complexes and 3 distinct clades in the US.

Sunbeam is a modular pipeline for metagenomic analysis that standardizes preprocessing and removes low-complexity reads, enabling reproducible and extensible workflows.