The paper investigates synapto-nuclear signaling defects in mSOD1 mice and shows that restoring cAMP/PKA signaling mitigates pathology in motoneurons.

bioRxiv · Sep 4, 2026 · PreprintNeuroscience

Spinal motoneuron excitability is homeostatically-regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice

Stefano Antonucci, Guillaume Caron, Natalie Dikwella, Sruthi Sankari Krishnamurthy, Anthony Harster, Bartosz Wasicki, Hina Zarrin, Aboud Tahanis, Florian olde Heuvel, Simon M. Danner, Albert Christian Ludolph, Kamil Grycz, Marcin Bączyk, Daniel Zytnicki, Francesco Roselli

This study shows that β-adrenergic receptors regulate spinal motoneuron excitability through homeostatic feedback in both wild-type and presymptomatic SOD1 mice.

Progress in Neurobiology · Mar 10, 2026Peer-reviewedNeuroscience

Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration

Filipe Nascimento, Mustafa Görkem Özyurt, Kareen Halablab, Gardave Singh Bhumbra, Guillaume Caron, Marcin Bączyk, Daniel Zytnicki, Marin Manuel, Francesco Roselli, Robert M. Brownstone, Marco Beato

The paper investigates how spinal microcircuits adapt in a mouse model of motoneuron degeneration, finding specific multiphasic homeostatic compensations that preserve force output.

Cell Reports · Dec 1, 2024Peer-reviewedNeuroscience