Simon M. Danner

Defective synapto-nuclear signaling contributes to motoneuron vulnerability in SOD1-ALS

The paper investigates synapto-nuclear signaling defects in mSOD1 mice and shows that restoring cAMP/PKA signaling mitigates pathology in motoneurons.

Spinal motoneuron excitability is homeostatically-regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice

This study shows that β-adrenergic receptors regulate spinal motoneuron excitability through homeostatic feedback in both wild-type and presymptomatic SOD1 mice.

Mechanisms of adaptive interlimb coordination to sudden ground loss: a neuromusculoskeletal modeling study

This study uses a neuromusculoskeletal model to show how afferent feedback enables adaptive interlimb coordination in cats after sudden ground loss, without re-optimizing parameters.

KCC2 Enhancers Normalize Reflex Responses and Improve Locomotor Function after Chronic Spinal Cord Injury

This study shows that enhancing KCC2 activity normalizes reflex responses and improves locomotor function in chronic spinal cord injury rats.

Reorganization of spinal neural connectivity following recovery after thoracic spinal cord injury: insights from computational modelling

This study uses computational models to explore how spinal neural connectivity reorganizes after thoracic spinal cord injury in rats, identifying key circuit-level changes that enable recovery.

Sensory Feedback and Central Neuronal Interactions in Mouse Locomotion

This study develops a mathematical model of mouse locomotion to investigate the roles of sensory feedback and central interactions in gait control.

Investigating the roles of reflexes and central pattern generators in the control and modulation of human locomotion using a physiologically plausible neuromechanical model

This paper presents a physiologically plausible neuromechanical model to study spinal control of human locomotion, showing that CPGs are necessary for rhythmic movement and that reflexes primarily provide inhibitory feedback.

Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information

The paper identifies the roles of V0 and V3 commissural interneurons in crossed reflexes in mice, showing V3 CINs are essential for both excitatory and inhibitory CRs, while V0 CINs modulate inhibitory CRs.

Spinal control of locomotion before and after spinal cord injury

This study examines how spinal cord injury affects locomotion speed and gait in rats, revealing changes in gait patterns and coordination after injury.

The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice

The paper investigates the role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice, finding that V3 aLPNs mediate synchronization between diagonal limb rhythm generators for trot and promote left-right synchronization for gallop and bound.

On the organization of the locomotor CPG: insights from split-belt locomotion and mathematical modeling

This paper investigates the organization of locomotor CPG circuits by testing a hypothesis about state-dependent changes in rhythm generator operation using experimental and mathematical modeling approaches.

Spinal V3 interneurons and left-right coordination in mammalian locomotion

This study investigates the role of V3 interneurons in left-right coordination during locomotion using experimental and computational approaches.