Lipid Disbalance Affects Neuronal Dendrite Growth and Maintenance in a Human Ceramide Synthase Disease Model
Anna B. Ziegler, Cedrik Wesselmann, Konstantin Beckschäfer, Anna‐Lena Wulf, Neena Dhiman, Peter Soba, Christoph Thiele, Reinhard Bauer, Gaia Tavosanis
The paper shows that lipid imbalances in a Drosophila model of PME8 cause dendrite loss and that restoring specific ceramides while reducing bioactive lipids rescues the phenotype.
bioRxiv · Oct 31, 2024 · PreprintNeuroscience