Targeting the homeodomain of ceramide-synthase can ameliorate insulin resistance
Christian Vera-Granda, Mariangela Sociale, Konstantin Beckschäfer, Ilja Kanevskij, Merlin Gerding, Franka Eckardt, Hannah Rindsfuesser, Christoph Thiele, Anna B. Ziegler, Margret Helene Bülow, Reinhard Bauer
The paper shows that mutations in the CerS homeodomain can either worsen or improve insulin resistance in Drosophila under high sugar diet conditions.
bioRxiv · Jul 24, 2025 · PreprintGenetics