Raf-MEK-ERK signaling mediates FLT3-induced mechanical allodynia and reduced morphine analgesic efficacy in male rodents
Jean-Philippe Leyris, Danae Ajas, Juliette Bertin, Chamroen Sar, Sylvie Mallié, Thiago M Cunha, Fabrice Ango, Hamid Moha-Ou-Maati, Ilana Méchaly, Jean Valmier, Cyril Rivat
This study identifies Raf-MEK-ERK signaling as a pathway linking FLT3 activation to nociceptor sensitization and reduced morphine efficacy in rodents.
bioRxiv · Oct 11, 2026 · PreprintNeuroscience