Thiago M Cunha

Raf-MEK-ERK signaling mediates FLT3-induced mechanical allodynia and reduced morphine analgesic efficacy in male rodents

This study identifies Raf-MEK-ERK signaling as a pathway linking FLT3 activation to nociceptor sensitization and reduced morphine efficacy in rodents.

DRG meningeal tertiary lymphoid structures are regulated by B cells as a pronociceptive locus after peripheral nerve injury

The paper shows that B cell-derived IgG in DRG meninges forms tertiary lymphoid structures (TLSs) that drive neuropathic pain after peripheral nerve injury, and disrupting TLSs prevents pain.

Nav1.5 expressed in TrkB+ sensory neurons mediates paclitaxel-induced mechanical pain hypersensitivity

This study identifies Nav1.5 in TrkB+ sensory neurons as a driver of paclitaxel-induced mechanical pain hypersensitivity in mice, with potential translational relevance to humans.