Chang-Qing Li

Reversal of microRNA-blocked tumor suppressors by biphenyl- dicarboxylate impedes endotoxin-induced hepatic hyperplasia

This study shows BPDC reverses microRNA-mediated suppression of tumor suppressors, reducing hepatic hyperplasia induced by LPS.

Short-hairpin RNA-guided single gene knockdown reverses triple-negative breast cancer

This study uses shRNA to knockdown iNOS and ER in breast cancer cells, showing that reducing iNOS inhibits TNBC growth while reducing ER promotes cancer-like features.

Insulin Does Not Augment In Vitro Tumor Growth Under A Hyperglycemia-Mimicking Milieu And In A Calorie Restriction-Resembling Manner

The paper shows insulin does not promote tumor growth in a hyperglycemic environment or under calorie restriction conditions in rat pituitary adenoma cells.

Artemisinin mimics nitric oxide to reduce adipose weight by targeting mitochondrial complexes

This study shows artemisinin reduces visceral adipose weight in obese mice by targeting mitochondrial complexes, mimicking nitric oxide's effects to improve mitochondrial function and reduce inflammation.

Chondroitin Sulfate Flourishes Gut Sulfatase-Secreting Bacteria To Damage Mucus Layers, Leak Bacterial Debris, And Trigger Inflammatory Lesions In Mice

This study shows that chondroitin sulfate feeding in mice increases sulfatase-secreting bacteria, damages mucus layers, and causes systemic inflammation and multi-organ pathologies.

Chondroitin sulfate elicits systemic pathogenesis in mice by interfering with gut microbiota homeostasis

This study shows that chondroitin sulfate induces steatogenesis, atherogenesis, and dementia-like pathogenesis in mice by disrupting gut microbiota homeostasis.