Qin Xu

Reaction-Conditioned Enzyme Discovery with Multimodal Deep Learning

This paper introduces VenusRXN, a deep learning framework for reaction-conditioned enzyme discovery, achieving high accuracy in identifying enzymes for novel reactions.

PI3Kdelta promotes T cell effector differentiation and plasticity during chronic infection

This study shows that activated PI3Kdelta reduces TCF-1+ stem-like CD8+ T cells but promotes effector differentiation and viral control during chronic infection.

Spatial Morphoproteomic Features Predict Uniqueness of Immune Microarchitectures and Responses in Lymphoid Follicles

The paper introduces SNOWFLAKE, a graph neural network framework that predicts disease status from multiplex imaging data in human B-cell follicles, showing improved performance over other methods.

Reversal of microRNA-blocked tumor suppressors by biphenyl- dicarboxylate impedes endotoxin-induced hepatic hyperplasia

This study shows BPDC reverses microRNA-mediated suppression of tumor suppressors, reducing hepatic hyperplasia induced by LPS.

Short-hairpin RNA-guided single gene knockdown reverses triple-negative breast cancer

This study uses shRNA to knockdown iNOS and ER in breast cancer cells, showing that reducing iNOS inhibits TNBC growth while reducing ER promotes cancer-like features.

Insulin Does Not Augment In Vitro Tumor Growth Under A Hyperglycemia-Mimicking Milieu And In A Calorie Restriction-Resembling Manner

The paper shows insulin does not promote tumor growth in a hyperglycemic environment or under calorie restriction conditions in rat pituitary adenoma cells.

Artemisinin mimics nitric oxide to reduce adipose weight by targeting mitochondrial complexes

This study shows artemisinin reduces visceral adipose weight in obese mice by targeting mitochondrial complexes, mimicking nitric oxide's effects to improve mitochondrial function and reduce inflammation.

Chondroitin Sulfate Flourishes Gut Sulfatase-Secreting Bacteria To Damage Mucus Layers, Leak Bacterial Debris, And Trigger Inflammatory Lesions In Mice

This study shows that chondroitin sulfate feeding in mice increases sulfatase-secreting bacteria, damages mucus layers, and causes systemic inflammation and multi-organ pathologies.

Chondroitin sulfate elicits systemic pathogenesis in mice by interfering with gut microbiota homeostasis

This study shows that chondroitin sulfate induces steatogenesis, atherogenesis, and dementia-like pathogenesis in mice by disrupting gut microbiota homeostasis.

FPD: A comprehensive phosphorylation database in fungi

The paper introduces FPD, a database of phosphorylation sites in fungi, containing 62,272 non-redundant sites across eight species.