A novel missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish
Jillian L. Ellis, Kimberley Jane Evason, Changwen Zhang, Makenzie N. Fourman, Jiandong Liu, Nikolay Ninov, Marion Delous, Benoît Vanhollebeke, Ian T. Fiddes, Jessica P. Otis, Yariv J. Houvras, Steven Arthur Farber, Xiaolei Xu, Xueying Lin, Didier Y. R. Stainier, Chunyue Yin
This study identifies a missense mutation in the furinb gene in zebrafish that causes hepatic cysts by disrupting ER homeostasis and mTOR signaling during liver development.
Hepatology Communications · Aug 26, 2022Peer-reviewedDevelopmental Biology