Xiaolei Xu

This study identifies genetic risk loci for doxorubicin-induced arrhythmia through GWAS meta-analysis and validates their functional relevance in human and zebrafish models.

This study uses zebrafish mutants to identify genetic modifiers of kidney cysts, finding that mtor and ulk1a inhibition can reverse cyst-related abnormalities.

The paper identifies an mTOR-Tfeb-Fabp7a signaling pathway that can repair proteostasis defects and cardiac dysfunction in zebrafish BAG3 cardiomyopathy.

This paper presents a zebrafish model of Leigh Syndrome, demonstrating liver dysfunction's critical role in mitochondrial disease through genetic rescue.

This study identifies Dnajb6 as a gene causing sick sinus syndrome through a phenotype-based genetic screen in zebrafish.

This study identifies a missense mutation in the furinb gene in zebrafish that causes hepatic cysts by disrupting ER homeostasis and mTOR signaling during liver development.

The paper presents a collection of zebrafish genetic mutants for studying mitochondrial biology and disease.

This paper establishes an adult zebrafish model of PKD using tmem67 mutants, identifies mTOR inhibition as a potential therapy, and reveals ciliary abnormalities as a primary defect.

The paper shows that vascular injury leads to changes in vessel network topology to increase blood flow and activate Notch-ephrinb2 signaling for microcirculation restoration.

The paper identifies SORBS2 as a new susceptibility gene for arrhythmogenic right ventricular cardiomyopathy (ARVC) using zebrafish and mouse models and human patient sequencing.

The paper describes a zebrafish gene break transposon library for genomic discovery and disease modeling, identifying novel gene expression patterns and generating models for human disease loci.

This study identifies RXRA as a therapeutic target for doxorubicin-induced cardiomyopathy in zebrafish by showing its endothelial-specific function and response to FDA-approved agonists.

This paper introduces a method to engineer precise deletions in the mitochondrial genome using TALE proteins in zebrafish and human cells.