Jiandong Liu

The paper shows that atrial peristalsis drives the transition from a bicuspid to quadricuspid valve in zebrafish through Klf2a-Snai1b signaling and shear stress alignment.

The paper creates a temporal and spatial atlas of postnatal heart development using single-nucleus transcriptomics and spatial transcriptomics, identifying 21 novel regulators of cardiomyocyte maturation through a new method called PIP-seq.

POLARIS infers cell composition from histology images and identifies layer-specific differentially expressed genes in spatial transcriptomics data.

This study identifies a missense mutation in the furinb gene in zebrafish that causes hepatic cysts by disrupting ER homeostasis and mTOR signaling during liver development.

This paper investigates the role of f3a in zebrafish development, finding that its knockdown causes defective angiogenesis and mild bleeding.

The paper profiles the transcriptome of the zebrafish atrioventricular canal to identify molecular signatures of pacemaker and valve mesenchyme, revealing conserved features with mammalian AV node and cardiac valves.

iSMNN improves batch effect correction in scRNA-seq by iteratively refining mutual nearest neighbors, enhancing cell type mixing and differential gene identification across batches.