Author

Charley Mackenzie-Kludas

The University of Melbourne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:multiome· 1

Frequent Co-Authors

Kanta SubbaraoiD· 2 shared Adam K. WheatleyiD· 1 shared Andrew P. KellyiD· 1 shared Anupriya AggarwaliD· 1 shared CheeLeng Lee· 1 shared Christine LangeriD· 1 shared Colin William PoutoniD· 1 shared Fasséli CoulibalyiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

Kanta SubbaraoORCID

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2 papers

Recent·Most cited

High-stability, clamp-free soluble Sarbecovirus spike trimers and their potential for pan-Sarbecovirus vaccine development.

Christine Langer, Irene Boo, Tasnim Zakir, Charley Mackenzie-Kludas, Johnson Samuel, Stewart A. Fabb, CheeLeng Lee, Anupriya Aggarwal, Stuart Grant Turville, Colin William Pouton, Kanta Subbarao, Fasséli Coulibaly, Heidi E. Drummer, Pantelis Poumbourios

This paper develops stable, clamp-free Sarbecovirus spike trimers for vaccine development, showing they elicit high neutralizing antibodies and broad protection in mice.

bioRxiv · Sep 14, 2025 · PreprintMicrobiology

De novo administration of antiviral monoclonal antibodies against SARS-CoV-2 or influenza using mRNA lipid nanoparticles

Mai N. Vu, Jessica Anne Neil, Charley Mackenzie-Kludas, Andrew P. Kelly, Hyon Xhi Tan, Kanta Subbarao, Wen Shi Lee, Adam K. Wheatley

This study compares traditional mAb infusion with mRNA/LNP-based de novo mAb expression in mice, finding high serum concentrations but compromised protective capacity due to anti-drug antibodies.

bioRxiv · Jul 23, 2025 · PreprintImmunology