ATP Citrate Lyase Drives Vascular Remodeling Diseases Development Through Metabolic-Epigenetic Reprograming.
Yann Grobs, Charlotte Romanet, Sarah-Eve Lemay, Alice Bourgeois, Pierre Voisine, Charlie Theberge, Melanie Sauvaget, Sandra Breuils-Bonnet, Sandra Martineau, Reem El Kabbout, Manon Mougin, Elizabeth Dumais, Jean Perron, Nicolas Flamand, François Potus, , Sebastien Bonnet
This study identifies ATP-citrate lyase as a driver of vascular remodeling in pulmonary hypertension and coronary artery disease, showing its inhibition can reverse pathological changes.
bioRxiv · Feb 2, 2024 · PreprintPhysiology