Aberrant chromatin looping by NUP98-HOXA9 is constrained by CTCF and facilitated by cohesin
Tooba Rashid, Zachary Drum, Ivana Yoseli Quiroga, Doris Cruz Alonso, Gelila Petros, Eric Davis, Benjamin Kornegay, Chelsea Yang, Chenxi Xu, Sylvie M. Parkus, Gang Greg Wang, Wesley R. Legant, Jill M. Dowen, Douglas H. Phanstiel
This study investigates how NUP98-HOXA9 drives aberrant chromatin looping in AML by interacting with CTCF and cohesin, revealing a non-canonical mechanism involving phase separation and loop extrusion.
bioRxiv · Jun 23, 2026 · PreprintMolecular Biology