Author

Sylvie M. Parkus

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:Hi-C· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:CUT&Tag· 1

Frequent Co-Authors

Douglas H. PhanstieliD· 3 shared Brian O. DiekmaniD· 2 shared Eliza ThulsoniD· 2 shared Jacqueline ShineiD· 2 shared Nicole E. KrameriD· 2 shared Philip CoryelliD· 2 shared Richard F. LoeseriD· 2 shared Seyoun ByuniD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersGenetics

Douglas H. PhanstielORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Aberrant chromatin looping by NUP98-HOXA9 is constrained by CTCF and facilitated by cohesin

Tooba Rashid, Zachary Drum, Ivana Yoseli Quiroga, Doris Cruz Alonso, Gelila Petros, Eric Davis, Benjamin Kornegay, Chelsea Yang, Chenxi Xu, Sylvie M. Parkus, Gang Greg Wang, Wesley R. Legant, Jill M. Dowen, Douglas H. Phanstiel

This study investigates how NUP98-HOXA9 drives aberrant chromatin looping in AML by interacting with CTCF and cohesin, revealing a non-canonical mechanism involving phase separation and loop extrusion.

bioRxiv · Jun 23, 2026 · PreprintMolecular Biology

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk

Nicole E. Kramer, Seyoun Byun, Philip Coryell, Susan D’Costa, Eliza Thulson, HyunAh Kim, Sylvie M. Parkus, Marielle L. Bond, Emma R. Klein, Jacqueline Shine, Susanna Chubinskaya, Michael I. Love, Karen L. Mohlke, Brian O. Diekman, Richard F. Loeser, Douglas H. Phanstiel

The paper identifies OA risk genes by integrating eQTLs, chromatin accessibility, and 3D chromatin structure in human chondrocytes, revealing 13 putative risk genes, 10 of which are novel.

Cell Genomics · Jan 1, 2025Peer-reviewedGenetics

Response splicing QTLs in primary human chondrocytes identifies putative osteoarthritis risk genes

Seyoun Byun, Philip Coryell, Nicole Kramer, Susan D’Costa, Eliza Thulson, Jacqueline Shine, Sylvie M. Parkus, Susan Chubinskaya, Richard F. Loeser, Brian O. Diekman, Douglas H. Phanstiel

The paper identifies response splicing QTLs in human chondrocytes and links them to osteoarthritis risk genes through alternative splicing analysis.

bioRxiv · Nov 11, 2024 · PreprintGenetics