Dual-mode tethered intramolecular agonist-dependent mechanoactivation of the adhesion GPCR ADGRG1/GPR56
Chaoyu Fu, Cheng Quan, Lina Zielke, Yuan Weng, Ying Zhang, Gaojie Song, Tobias Langenhan, Jie Yan
This study investigates the mechanotransduction mechanism of ADGRG1/GPR56, revealing a dual-mode activation process that does not require NTF-CTF dissociation and depends on the Stachel element.
bioRxiv · Sep 16, 2025 · PreprintCell Biology