Jie Yan

This study examines how sequence differences between talin-1 and talin-2 affect their mechanical responses and ligand-binding capabilities, revealing distinct mechanical behaviors and new interaction sites in talin-2.

The paper shows that the A50I vinculin mutation is not talin-binding-null and that talin is essential for organizing vinculin tension gradients in focal adhesions.

This paper identifies an aggregation-prone region in talin that drives self-interactions and regulates integrin adhesion complex dynamics through mechanical unfolding and oligomerization.

This study investigates the mechanotransduction mechanism of ADGRG1/GPR56, revealing a dual-mode activation process that does not require NTF-CTF dissociation and depends on the Stachel element.

This study shows SMCHD1 directly compacts DNA in a flexible, ATP-independent manner, forming clusters that may contribute to gene silencing and genome organization.

This study solves the structure of the E. coli TolQRA complex using cryo-EM to elucidate the mechanism of force transduction across the cell envelope.

This study shows that miR-205 modulates the mechanical properties of hair follicle stem cells and progenitors to promote hair regeneration.

This study investigates the holdase function of Escherichia coli DnaK chaperone using single-molecule assays, showing it stabilizes unfolded proteins and switches between holding and releasing states upon ATP binding.