Gaojie Song

This study investigates the mechanotransduction mechanism of ADGRG1/GPR56, revealing a dual-mode activation process that does not require NTF-CTF dissociation and depends on the Stachel element.

This paper develops eTd-mtABEs, engineered mitochondrial A-to-G base editors with enhanced efficiency and targeting scope, enabling efficient generation of mtDNA disease models in rat embryos.

The paper determines the crystal structure of a constitutive active A2A receptor mutant to elucidate the molecular mechanism of mutation-induced activity.