Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration
Dong Liu, Hannah C. Webber, Fuyun Bian, Yangfan Xu, Manjari Prakash, Xue Feng, Ming Wen Ou Yang, Hang Yang, In‐Jee You, Liang Li, Liping Liu, Pingting Liu, Haoliang Huang, Chien-Yi Chang, Liang Liu, , Yang Hu
This study identifies OPTN's role in axonal mitochondria transport and shows its loss contributes to neurodegeneration in models of ALS and NTG.
Nature Communications · Feb 20, 2025Peer-reviewedNeuroscience