Age-Dependent Effects of Macrophage Derived Cathelicidin Antimicrobial Peptide on Bone Fracture Repair
Tuyet Nguyen, Yasuhito Yahara, Eijiro Shimada, Vijitha Puviindran, Vijitha Puviindran, Koji Ishikawa, Choiselle Marius, Benjamin Aaron Alman
This study identifies cathelicidin antimicrobial peptide (CAMP) as an age-dependent regulator of bone fracture repair, showing it promotes healing in young mice but limits it in aged mice through P2X7R-NLRP3 signaling.
bioRxiv · Sep 30, 2026 · PreprintCell Biology