Tuyet Nguyen

Age-Dependent Effects of Macrophage Derived Cathelicidin Antimicrobial Peptide on Bone Fracture Repair

This study identifies cathelicidin antimicrobial peptide (CAMP) as an age-dependent regulator of bone fracture repair, showing it promotes healing in young mice but limits it in aged mice through P2X7R-NLRP3 signaling.

Muscle-to-Bone CX3CL1 Signaling Promotes Skeletal Repair Through CX3CR1+ Osteoprogenitors

This study identifies a muscle-to-bone signaling pathway where CX3CL1 from muscle endothelial cells promotes bone repair via CX3CR1-expressing osteoprogenitors.

Hypertrophic Chondrocytes Serve as a Reservoir for Marrow Associated Skeletal Stem and Progenitor Cells, Osteoblasts, and Adipocytes During Skeletal Development

The paper shows hypertrophic chondrocytes dedifferentiate into marrow-associated stem/progenitor cells that contribute to osteoblasts, adipocytes, and bone marrow establishment during skeletal development.