Shyni Varghese

Engineered nanosponges mitigate peripheral stress-induced neuroinflammation and restore cognitive function

This study develops HA Tau nanosponges that reduce systemic inflammation and cognitive decline in aged mice by sequestering inflammatory proteins without suppressing immunity.

Patient-Specific Vascularized Lung Tumor Organoids for Tumor-Immune Profiling

This paper develops a vascularized tumor organoid platform to model patient-specific immunotherapy responses and identifies hyperangiogenic signaling as a barrier to T cell infiltration.

Muscle-to-Bone CX3CL1 Signaling Promotes Skeletal Repair Through CX3CR1+ Osteoprogenitors

This study identifies a muscle-to-bone signaling pathway where CX3CL1 from muscle endothelial cells promotes bone repair via CX3CR1-expressing osteoprogenitors.

UDP-6-glucose dehydrogenase in hormonally responsive breast cancers

This study shows that UGDH knockdown reduces estrogen-induced tumorigenic traits in breast cancer models and validates findings in human clinical specimens.