Author

Christina Antoniou

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Andrea LoretoiD· 2 shared Elisa Merlini· 2 shared Giuseppe OrsomandoiD· 2 shared Michael P. ColemaniD· 2 shared David BennettiD· 1 shared Elliot D. MockiD· 1 shared Hien Tran ZhaoiD· 1 shared Ilenia CirilliiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersNeuroscience

Andrea LoretoORCID

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2 papers

Recent·Most cited

SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides

Andrea Loreto, Kaitlyn M. L. Cramb, Lucy McDermott, Christina Antoniou, Ilenia Cirilli, Maria Claudia Caiazza, Elisa Merlini, Peter Arthur‐Farraj, Willem Daniel du Preez, Elliot D. Mock, Hien Tran Zhao, David Bennett, Giuseppe Orsomando, Michael P. Coleman, Richard Wade‐Martins

This study shows that SARM1 activation causes mitochondrial dysfunction in human neurons, which can be reversed by nicotinamide or prevented by antisense oligonucleotides.

Neurobiology of Disease · Jun 3, 2025Peer-reviewedNeuroscience

Chronically low NMNAT2 expression causes sub-lethal SARM1 activation and altered response to nicotinamide riboside in axons

Christina Antoniou, Andrea Loreto, Jonathan Gilley, Elisa Merlini, Giuseppe Orsomando, Michael P. Coleman

This study shows that low NMNAT2 levels cause sub-lethal SARM1 activation and reduce the effectiveness of nicotinamide riboside in axons, leading to axonal defects and behavioral changes in mice.

Molecular Neurobiology · Oct 1, 2024Peer-reviewedNeuroscience