Peter Arthur‐Farraj

The paper identifies integrin and BMP signaling pathways that drive OPC-to-SC differentiation in CNS regeneration using single-cell genomics.

This study shows that SARM1 activation causes mitochondrial dysfunction in human neurons, which can be reversed by nicotinamide or prevented by antisense oligonucleotides.

This study introduces a novel laser-induced axotomy method in adult mice to study axonal degeneration and regeneration dynamics, revealing delayed degeneration in Sarm1-null mice.

This paper introduces a novel mouse myelinating Schwann cell-DRG coculture system to study axon protection and degradation after injury.

The paper shows SARM1 is present in oligodendrocytes but not Schwann cells, and its deletion does not affect myelination in zebrafish or mice.

This study identifies VMN, a metabolite of the pesticide vacor, as a potent SARM1 activator, showing that SARM1 removal rescues vacor-induced neuron and axon death.

The paper shows that restoring Schwann cell c-Jun rescues nerve regeneration failures in aging and chronic denervation by enhancing regenerative support.