A mutation in the transmembrane domain of Adenylate cyclase 3 impairs enzymatic function to cause sex-specific depression- and anxiety-like behaviors and food seeking in a rat model
Mackenzie K. Fitzpatrick, Christina Dyson, Angela Beeson, Leighelle Adrian, Glen S. Marrs, Michael N. Grzybowski, Jason Klotz, Aron M. Geurts, Rong Chen, Jeffrey L. Weiner, Leah C. Solberg Woods
This study shows that a mutation in the transmembrane domain of Adcy3 in rats leads to sex-specific changes in adiposity, behavior, and cAMP production.
Genes Brain & Behavior · Jun 1, 2025Peer-reviewedNeuroscience