Aron M. Geurts

This study maps the molecular landscape of hypertension using single-cell data from multiple organs and models, linking genetic variants to disease mechanisms.

The paper develops rat models with modified sex chromosomes to study sex differences in physiology and disease by comparing XX vs. XY and varying X/Y chromosome numbers.

The paper investigates the functional role of recursive splicing in CADM2, showing that its deletion leads to altered gene expression and behavioral changes in neurodevelopmental disorders.

The paper maps chromatin interactions in human arterioles, linking genetic variants to gene expression and hypertension mechanisms.

The paper investigates the physiological role and mechanisms of a noncoding haplotype associated with blood pressure by combining animal models, genome editing, and chromatin analysis.

This study shows that a mutation in the transmembrane domain of Adcy3 in rats leads to sex-specific changes in adiposity, behavior, and cAMP production.

The paper maps epigenetic and genetic regulation in human endothelial and vascular smooth muscle cells, showing strong correlations between gene expression and chromatin features, and demonstrates SNP effects on gene expression through chromatin loops.

This study shows that a protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors in rats, with sex-dependent effects on metabolism and behavior.

The paper presents an improved rat reference genome, mRatBN7.2, which enhances genomic, transcriptomic, and proteomics data mapping and identifies millions of genetic variations across rat strains.

This study shows that Krtcap3 knock-out rats exhibit increased adiposity and anxiety under chronic stress, with altered corticosterone responses and Nr3c1 expression.

The paper investigates the failure to replicate an adiposity phenotype linked to Krtcap3 in rats, hypothesizing that environmental stress changes during the COVID-19 pandemic may have influenced the results.

This study shows that disrupting Sxc-mediated glutamate release from astrocytes in rats increases negative-outcome behaviors without affecting basic brain functions.

This study confirms that Krtcap3 affects adiposity and demonstrates sex-specific effects on body weight, food intake, and insulin sensitivity in rats.