Michael N. Grzybowski

A single-cell map of hypertension

This study maps the molecular landscape of hypertension using single-cell data from multiple organs and models, linking genetic variants to disease mechanisms.

Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more

The paper develops rat models with modified sex chromosomes to study sex differences in physiology and disease by comparing XX vs. XY and varying X/Y chromosome numbers.

Aberrant recursive splicing in a human disease locus

The paper investigates the functional role of recursive splicing in CADM2, showing that its deletion leads to altered gene expression and behavioral changes in neurodevelopmental disorders.

Chromatin interaction maps of human arterioles reveal new mechanisms for the genetic regulation of blood pressure

The paper maps chromatin interactions in human arterioles, linking genetic variants to gene expression and hypertension mechanisms.

Physiological role and mechanisms of action for a long noncoding haplotype region

The paper investigates the physiological role and mechanisms of a noncoding haplotype associated with blood pressure by combining animal models, genome editing, and chromatin analysis.

A mutation in the transmembrane domain of Adenylate cyclase 3 impairs enzymatic function to cause sex-specific depression- and anxiety-like behaviors and food seeking in a rat model

This study shows that a mutation in the transmembrane domain of Adcy3 in rats leads to sex-specific changes in adiposity, behavior, and cAMP production.

Protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors sex-dependently in rats

This study shows that a protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors in rats, with sex-dependent effects on metabolism and behavior.

Chronic Stress Increases Adiposity and Anxiety in Rats with Decreased Expression of Krtcap3

This study shows that Krtcap3 knock-out rats exhibit increased adiposity and anxiety under chronic stress, with altered corticosterone responses and Nr3c1 expression.

Changes in Environmental Stress over COVID-19 Pandemic Likely Contributed to Failure to Replicate Adiposity Phenotype Associated with Krtcap3

The paper investigates the failure to replicate an adiposity phenotype linked to Krtcap3 in rats, hypothesizing that environmental stress changes during the COVID-19 pandemic may have influenced the results.

Genetic Disruption of System xc- Mediated Glutamate Release from Astrocytes Increases Negative-Outcome Behaviors While Preserving Basic Brain Function in Rat

This study shows that disrupting Sxc-mediated glutamate release from astrocytes in rats increases negative-outcome behaviors without affecting basic brain functions.

Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred rats

Keratinocyte-Associated Protein 3 is a novel gene for adiposity with differential effects in males and females

This study confirms that Krtcap3 affects adiposity and demonstrates sex-specific effects on body weight, food intake, and insulin sensitivity in rats.