Angela Beeson

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats

This study performs a GWAS on cocaine self-administration in rats, identifying six genome-wide significant loci, including one linked to carboxylesterase genes involved in cocaine metabolism.

A mutation in the transmembrane domain of Adenylate cyclase 3 impairs enzymatic function to cause sex-specific depression- and anxiety-like behaviors and food seeking in a rat model

This study shows that a mutation in the transmembrane domain of Adcy3 in rats leads to sex-specific changes in adiposity, behavior, and cAMP production.

A multi-symptomatic model of heroin use disorder in rats reveals distinct behavioral profiles and neuronal correlates of heroin vulnerability versus resiliency

This study uses a non-linear clustering approach in rats to identify distinct behavioral and neuronal profiles associated with heroin vulnerability and resiliency, reflecting human opioid use disorder heterogeneity.

Protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors sex-dependently in rats

This study shows that a protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors in rats, with sex-dependent effects on metabolism and behavior.

Y and Mitochondrial Chromosomes in the Heterogeneous Stock Rat Population

The paper genotypes Y and mitochondrial chromosomes in heterogeneous stock rats and finds no significant associations with complex traits, except for gene expression on these chromosomes.

Genome-wide association study of delay discounting in Heterogenous Stock rats

This study identifies genetic loci associated with delay discounting in Heterogenous Stock rats using GWAS, implicating Slc35f1 and Adgrl3 as potential genes involved in this behavior.

Chronic Stress Increases Adiposity and Anxiety in Rats with Decreased Expression of Krtcap3

This study shows that Krtcap3 knock-out rats exhibit increased adiposity and anxiety under chronic stress, with altered corticosterone responses and Nr3c1 expression.

Sex and genetic specific effects on behavioral, but not metabolic, responses to a high fat diet in heterogeneous stock rats

This study shows that high fat diet affects metabolic health similarly in male and female HS rats but only males show altered behavioral responses, with genetic factors influencing both outcomes.